Social & Contextual Impact on Children Undergoing Liver Transplantation (NCT04551742)
🩺 Plain-English Summary (8th-Grade Level)
The social determinants of health have a large impact on health. For example, neighborhood socioeconomic deprivation is associated with increased risk of medication non-adherence, graft failure, and death in children after liver transplant. In order to address these socioeconomic inequities in outcomes, a more granular understanding of how the social determinants of health impact outcomes is needed. In this observational prospective cohort, caregivers of children undergoing liver transplantation will complete surveys and undergo in-depth, qualitative interviews. The survey will assess comprehensively for the social determinants of health (e.g. material economic hardship, health literacy, social connectedness, primary care quality, etc). The qualitative interviews will identify barriers and facilitators that socioeconomically deprived children/families have to obtaining the ideal outcome and identify health system opportunities to integrate social needs and medical care. Data will be linked to an existing prospective cohort study (The Society for Pediatric Liver Transplant registry) to assess the impact of social risk on outcomes after transplant. Healthcare providers who take care of children undergoing liver transplant will also be included in the qualitative interviews. The goal of including this group in the study is to determine the health systems barriers and facilitators to social needs screening and intervention.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (8 items).
Location: Children's Hospital Los Angeles — Los Angeles, California
Age range: Not specified to 70 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria: Caregivers/parents of children undergoing liver transplantation will be excluded it:
- Caregiver unwilling or unable to complete the survey
- Child is a ward of the state (e.g., foster care) since present circumstances may not be reflective of child's past or future circumstances
- Non-English, non-Spanish speakers
- Non-US residents
- Declined participation in SPLIT Inclusion Criteria for Interview Portion of the Study:
- Participants who have completed the questionnaire OR
- Medical team member involved in the care of children undergoing liver transplant (e.g., physician, nurse, social worker)
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (8 Sites)
- Children's Hospital Los Angeles — Los Angeles, California
- Lucile Packard Children's Hospital — Palo Alto, California
- University of California San Francisco — San Francisco, California
- Children's Healthcare of Atlanta — Atlanta, Georgia
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio
- UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania
- Children's Medical Center Dallas — Dallas, Texas
- Seattle Children's Hospital — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Liver Transplantation
- Mediterranean Diet Post-liver Transplantation — Rochester, Minnesota
- Molecular Assessment and Profiling of Liver Transplant Recipients — Los Angeles, California
- Sequential Hypo- and Normo-thermic Perfusion to Preserve Extended Criteria Donor Livers for Transplantation — Cleveland, Ohio
- Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot — Vancouver, British Columbia
- Continued Access Study to Evaluate Performance of the Organ Recovery Systems _LifePort® Liver Transporter System, a Machine Perfusion System, for Liver Transplant (PILOT™_CA) — Chicago, Illinois
Explore by condition: All Liver Transplantation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.