Molecular Assessment and Profiling of Liver Transplant Recipients (NCT04793360)
🩺 Plain-English Summary (8th-Grade Level)
The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation. The primary aim will compare the clinical outcomes of LiverCare post-transplant surveillance in liver transplant with standard of care consisting of liver function tests, DSA measurements, drug level monitoring, and 'for cause' biopsy. The protocol will assess the correlation between clinical events (e.g. rejection, recurrent disease, biliary obstruction), dd-cfDNA levels, gene expression profiling, ability to assess microchimerism, develop predictive analytics, infectious disease diagnoses and finally examine graft histology.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (9 items).
Location: Keck Medical Center of USC — Los Angeles, California
Age range: 12 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Female participant who is pregnant, lactating or planning pregnancy during the course of the trial.
- Has evidence of significant post-transplant impairment of hepatic function which is unlikely to improve (determined by the PI).
- Scheduled elective surgery or other procedures requiring general anaesthesia during the trial.
- Participant with life expectancy of less than 6 months or is inappropriate for diagnostic monitoring through regular blood sampling.
- Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial.
- Participants who have participated in another research trial involving an investigational product in the past 12 weeks\*.
- Multi-organ transplant recipients or dual organ transplant recipients.
- Patients with significant needle phobia.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- Keck Medical Center of USC — Los Angeles, California
- MedStar Georgetown University Hospital — Washington D.C., District of Columbia
- Tampa General Hospital — Tampa, Florida
- Piedmont Healthcare — Atlanta, Georgia
- University of Kansas Medical Center — Kansas City, Kansas
- Tulane University — New Orleans, Louisiana
- University of Maryland Medical Center — Baltimore, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Beth Israel Deaconess Medical Center (BIDMC) — Boston, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- Henry Ford Health System — Detroit, Michigan
- Washington Unversity in St. Louis — St Louis, Missouri
- University of Nebraska Medical Center/ Nebraska Medicine — Omaha, Nebraska
- Icahn School of Medicine at Mount Sinai — New York, New York
- Westchester Medical Center — Valhalla, New York
- Atrium Health — Charlotte, North Carolina
- Duke University — Durham, North Carolina
- University of Cincinnati — Cincinnati, Ohio
- INTEGRIS Baptist Medical Center — Oklahoma City, Oklahoma
- Medical Unversity of South Carolina — Charleston, South Carolina
- University of Tennessee_Methodist Healthcare — Memphis, Tennessee
- Methodist Health System — Dallas, Texas
- Baylor College of Medicine — Houston, Texas
- Intermountain Medical Center — Murray, Utah
- Virginia Commonwealth University — Richmond, Virginia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Liver Transplantation
- Social & Contextual Impact on Children Undergoing Liver Transplantation — Los Angeles, California
- Mediterranean Diet Post-liver Transplantation — Rochester, Minnesota
- Sequential Hypo- and Normo-thermic Perfusion to Preserve Extended Criteria Donor Livers for Transplantation — Cleveland, Ohio
- Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot — Vancouver, British Columbia
- Continued Access Study to Evaluate Performance of the Organ Recovery Systems _LifePort® Liver Transporter System, a Machine Perfusion System, for Liver Transplant (PILOT™_CA) — Chicago, Illinois
Explore by condition: All Liver Transplantation clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.